Use of biogenic estrogen sulfamates for hormone replacement...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S178000, C514S182000, C514S874000

Reexamination Certificate

active

07053077

ABSTRACT:
The invention relates to the use of biogenic estrogen sulfamates for the oral discontinuous application for hormone replacement therapy (HRT). The discontinuous administration takes place in intervals ranging from 2 to 40 days. The invention also provides the additional application of gestagens, preferably continuously in the form of an implant or in the form of an intrauterine releasing system (IUD). Estrone sulfamate, estradiol sulfamate or an N-acyl sulfamate of estrone, estradiol or estriol having up to 7 C-atoms in the acyl chain, or a combination comprised of two or more of said active ingredients are used as biogenic estrogen sulfamates.

REFERENCES:
patent: 5314694 (1994-05-01), Gale et al.
patent: 5633242 (1997-05-01), Oettel
patent: 95 01161 (1995-01-01), None
patent: WO-96/05216- (1996-02-01), None
Elger, W. et al.: “Sulfamates of various estrogens are prodrugs with increased systemic and reduces hepatic estrogenicity at oral application.”Journal of Steroid Biochemisty and Molecular Biology, vol. 55, No. 3-4 pp. 395-403.
Elger, W et al. “Novel oestrogen sulfamates: a new approach to oral hormone therapy” vol. 7, No. 4, 1998 pp. 575-658.

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