Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1998-03-18
2000-04-11
Dees, Jos'G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514510, 514639, 514908, 552510, C07J 5300, A61K 3115, A61K 3121, A61K 3156
Patent
active
060488476
ABSTRACT:
The invention relates to use of betulinic acid and/or its derivatives for treating, inhibiting, and/or preventing tumors or cancer growth more particularly, to treating leukemia, lymphomas, lung, prostate and ovarian cancer. This invention also relates to novel betulinic acid derivatives and a composition containing betulinic acid derivatives with or without betulinic acid.
REFERENCES:
patent: 5679828 (1997-10-01), Lee et al.
patent: 5843974 (1998-12-01), Swift
patent: 5869535 (1999-02-01), Pezzuto et al.
Fujioka, et al, Journal of Natural Products, vol. 57, No. 2, Feb. 1, 1994, pp. 243-247.
Hashimoto, et al, Bioorg. Med., Chem., vol. 5, No. 12, 1997, pp. 2133-2143.
Konoshima T. et al., Journal of Natural Products, vol. 50, No. 6, Nov. 1, 1987, pp. 1167-1170.
Miles, D. H., et al., Journal of Pharmaceutical Sciences, vol. 63, No. 4, Apr. 1, 1974, pp. 613-615.
J.S. Lee, et al., Chemical Abstracts + Indexes, vol. 125 No. 19, Nov. 4, 1996, p. 58.
Bishay, D.W. et al., Bulletion of Pharmaceutical Sciences, vol. 10, Part 2, Jan. 1, 1987, pp. 1-20.
Toda, A. et al, Chemical Abstracts, vol. 127, No. 2, Abstract 023542, Jul. 14, 1997.
Pradhan, B.P., et al, Indian J. Chem., Sect. B., vol. 32B, No. 11, pp. 1178-1180.
Patra, A. et al, Chemical Abstracts, vol. 111, No. 9, Abstract 078441, Aug. 28, 1989.
Protiva, J. et al, Collection of Czechoslovak Chemical Communications, vol. 42, No. 4, 1977, pp. 1220-1228.
Protiva, J. et al, Collection of Czechoslovak Chemical Communications, vol. 41, No. 4, 1976, pp. 1200-1207.
Protiva, J. et al, Collection of Czechoslovak Chemical Communications, vol. 46, No. 11, 1981, pp. 2734-2741.
Akira Inada, et al., Chemical and Pharmaceutical Bulletin, Vo. 41, No. 3, Mar. 1, 1993, pp. 617-619.
Y. Noda, et al., Chemical and Pharmaceutical Bulletin, vol. 45, No. 10, Jan. 1, 1997, pp. 1665-1670.
Kim, D S H L, et al., Bioorganic & Medical Chemistry Letters, vol. 8, No. 13, Jul. 7, 1998, pp. 1707-1712.
Brenner, "Ovulation Inhibition with Nafarel in Acetate Nasal Administration for Six Months", Contraception, 1986.
Choi, Y., "Ellagic Acid Derivatives of Agrostistachys hookeri", Planta medica, 1988, pp. 511-513.
Inoue, H., "Inhibitory Effect of Glycyrrhetinic Acid Derivatives on Lipoxygenase and Prostaglandin Synthease", Chem. Pharm. Bull. vol. 34 (2), pp. 897-901, 1986.
Mosmann, T., "Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Prolieration and Cytoxicity Assays" Journal of Immunlogical Methods, vol. 65., 1983, pp. 55-63.
Pisha, E., "Discovery of Betulinic Acid as a Selective Inhibitior of Human Melanoma that Functions by Induction of Apoptosis" Nature Medicine, vol. 1, No. 10, Oct. 1995, pp. 1046-1051.
Waller, D.P., "In Vitro Spermicidal Activity of gossypol", Contraception, Aug. 1980, vol. 22, No. 2, pp. 183-188.
Yasukawa, "Sterol and Triterpene Derivatives from Plants Inhibit the Effects of a Tumor Promoter, and Sitosterol and Betulinic Acid Inhibit Tumor Formation in Mouse Skin Two-Stage Carcinogenic", Oncology, 46:72-76, 1991.
Delporte, C.L., "Biological Activities and Metabolites from Trevoa Trinervis Miers", Phytotherapy Research, vol. 11, 504-507 (1997).
Jaggi Manu
Ramadoss Sunder
Siddiqui Mohammad Jamshed Ahmad
Bado Barbara
Dabur Research Foundation
Dees Jos'G.
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