Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-11-24
1995-02-28
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514411, A61K 3140
Patent
active
053937724
ABSTRACT:
The present invention provides a new medical use of the hydroxycarbazole compounds of Formula (I), preferably the hydroxylated metabolites of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol)(carve dilol), for inhibiting the migration and proliferation of smooth muscle cells. In particular, the present invention provides a new use for the hydroxycarbazole compounds of Formula (I) for prevention of restenosis following percutaneous transluminal coronary angioplasty (PTCA), suppression of the progression of vascular hypertrophy associated with hypertension, and prevention of development of atherosclerosis. ##STR1## wherein: R.sub.1 -R.sub.9 are independently --H or --OH, with the proviso that a at least one of R.sub.1 -R.sub.9 is OH.
REFERENCES:
patent: 5308862 (1994-04-01), Ohlstein
Albrightson, C et al Pharmacol. Commun. (1992) 1(4) 267-272.
Ohlstein, E et al Proc. Natl. Acad. Sci U.S.A. 1993 90(13) 6189-93.
Sung, C et al, J. Cardiovasc. Pharmacology (1993) 21(2), 221-7.
Feuerstein Giora Z.
Ohlstein Eliot H.
Yue Tian-Li
Boehringer Mannheim Pharmaceuticals Corporation
Killos Paul J.
Lentz Edward T.
SmithKline Beecham Corporation Limited Prtnrshp No. 1
Stercho Yuriy P.
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