Use of 2-substituted-thiazolidine-4-carboxylic acids for treatme

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514912, A61K 31425

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active

053995732

ABSTRACT:
Compounds of the formula: ##STR1## are useful for treatment of cataracts in mammals.

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Garner, W. H., et al., "Mechanism of Delay of Galactosemic Cataract with Oxo-thiazolidine Carboxylic Acid (OTC)," Tuesday AM: Lens Poster Presentation, p. 147. (1988).
Nagasawa, H. T., et al., "2-Substituted Thiazolidine-4(R)-carboxylic Acids as Prodrugs of L-Cysteine. Protection of Mice against Acetaminophen Heptatoxicity," J. Med. Chem,, 1984, 27, 591-596.
Holleschan, A. M., et al., "Procedures for Augmenting Glutathione in Cultured Rabbit Lenses," Lens Research, 3(1-2), 1097-118, 1986.
Roberts, T. C., et al., "Prodrugs of L-Cysteine as Protective Agents against Acetaminophen-Induced Heptatoxicity. 2-(Polyhydroxyalkyl)-and 2-(Polyacetoxylalkyl)thiazolidine-4(R)-carboxylic Acids," J. Med. Chem, 1987, 30, 1891-1896.
Chemical Abstract 114(9): 75242m, 1990. Garner et al.

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