Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments

Details Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments

1989-09-22

1991-10-01

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

5142355, 5142368, 5142375, 514253, 514255, 514317, 514318, 514319, 514333, 514354, 514357, 514369, 514370, 514444, 514445, 514447, 514471, 514472, 514473, 514533, 514534, 514538, 514539, 514542, 514597, 514602, 514604, 514629, 544111, 544124, 544133, 544146, 544152, 544159, 544165, 544358, 544360, 544369, 544374, 544379, 544390, 546187, 546189, 546205, 546268, 546284, 546290, 546293, 546296, 546297, 546300, 548182, 548186, 548187, 548202, 548204, 548205, 549 62, 549 65, 549 66, 549 68, 549 74, 549 76, 54947

Patent

active

050534300

ABSTRACT:
Novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. These compounds are useful in the treatment of schizophrenia.

REFERENCES:
patent: 4320148 (1982-03-01), DeMarinis
patent: 4442126 (1984-04-01), Beeley et al.
patent: 4520030 (1985-05-01), Cavero et al.
Asselin et al., Drug Design via Pharmacophore Identification. Dopaminergic Activity of 3H-Benz[e]Indol-8-Amines and their Mode of Interaction with the Dopamine Receptor, J. Med. Chem. 29; 648-654 (1986).
A. Windaus, Uber Einige Derivate Des Ac.-Tetrahydro-.beta.-Naphthylamins; Berichte Der Deutschen Chemischen Gesellschaft, 57; Jahrgang; 1924, Band II, pp. 1731-1739 (Verlag Chemie; GmbH, Leipzig and Berlin).
Beilsteins Handbuch Der Organischen Chemie, 4; Erganzungswerk, 13; Band, 1950-1959; 4, Auflage, p. 328 (Springer-Verlag Berlin, Heidelberg, New York; Tokyo 1985).

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