Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-12-28
1989-04-04
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142352, 5142355, 5142358, 5142372, 5142368, 5142375, 544114, 544119, 544122, 544124, 544129, 544132, 544141, 544143, 544146, 544152, 544159, 544162, 544168, 544169, A61K 31535
Patent
active
048187577
ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
REFERENCES:
patent: 4329473 (1982-03-01), Almquist et al.
patent: 4621092 (1986-11-01), Natarajan et al.
patent: 4623729 (1986-11-01), Natarajan et al.
Meyer et al., "Novel Synthesis of . . . ", J. Med. Chem., 1981, vol. 24, pp. 964-969.
Almquist et al., "Derivatives of Potent Angiotensin Converting Enzyme Inhibitor . . . ", J. Med. Chem., 1982, vol. 25, 1292-1299.
Gordon Eric M.
Weller, III Harold N.
Covington Raymond
Davis Stephen B.
E. R. Squibb & Sons Inc.
Hollrah Glennon H.
Levinson Lawrence S.
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