Urea/lactate topical compositions for dry skin

Details Urea/lactate topical compositions for dry skin Urea/lactate topical compositions for dry skin

1993-07-28

1996-10-01

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Carboxylic acid or salt thereof

514588, 514844, 514847, A61K 4712, A61K 3117

Patent

active

055611664

ABSTRACT:
Methods and compositions for the treatment of dry skin involve the topical application to affected sites of a composition comprising from about 1% to about 12% by weight of urea and from about 1% to about 10% by weight of and alkali or an earth metal salt of lactic acid such as sodium, potassium or calcium lactate or a mixture of these salts in water-in-oil emulsions. In lotion embodiments, the emulsion typically contains from about 1% to about 10% by weight, more narrowly from about 2% to about 5% by weight, lactate and from about 1% to about 10% by weight, more narrowly from about 2% to about 5% by weight, urea. In cream embodiments, the emulsion typically contains from about 1% to about 5% by weight, more narrowly from about 2% to about 4% by weight, lactate, and from about 3% to about 15% by weight, more narrowly from about 5% to about 10% by weight, urea. Application of the compositions of the invention to the skin controls transepidermal water loss and minimizes disturbance of the epidermal barrier layer.

REFERENCES:
patent: 4105782 (1978-08-01), Yu et al.
patent: 4246261 (1981-01-01), Van Scott et al.
patent: 4703041 (1987-10-01), Weber et al.
patent: 5091171 (1992-02-01), Yu et al.
patent: 5162378 (1992-11-01), Guthauser
patent: 5215759 (1993-06-01), Mausner
patent: 5216033 (1993-06-01), Pereira et al.
Ashton, H., et al., Br. J. Dermatol. 84: 194-196 (1971).
Blair, C., Br. J. Dermatol. 94: 145-153 (1976).
Harry et al, The Principle and Pratice of Modern Cosmetics, 1963, vol. 2, Cosmetic Materials, pp. 248, 249 & 520-523.
Blichmann, C. W. and Serup, J., Acta Derm. Venereol. (Stockh.) 68: 284-290 (1988).
Cecil's Textbook of Medicine, 17th ed., W. B. Saunders Co., Philadelphia, 1985, pp. 2240-2241.
Leveque, J. L., J. Soc. Cosmet. Chem. 82: 171-177 (1987).
Martindale Pharmacopeia, 29th edition, citing Report No. 179 of the General Practitioner Research Group, Practitioner 210: 294 (1973).
Physicians' Desk Reference, 45th ed., 1991, p. 2198.
Rogers, R. S., et al., J. Am. Acad. Dermatol. 21: 714-1989 (1991).
Swanbeck, G., Acta Derm. Venereol. 48: 123-127 (1968).
Tronnier, H., Arztl. Kosmetologie 10: 291-308 (1980) * Untranslated version in German.
Van Scott, E. J., and Yu, R. J., Cutis, 43: 222-228 (1989).

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