Urea derivatives having ACAT inhibitory activity, their preparat

Details Urea derivatives having ACAT inhibitory activity, their preparat Urea derivatives having ACAT inhibitory activity, their preparat

1998-05-28

2000-03-21

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

560130, 560133, 560138, 564 32, 564 47, 564 92, 564154, 564155, 564158, 514452, 514464, 514465, 514469, 514478, 514479, 514524, 514563, 514588, 514601, 514602, 514617, 514618, 514619, 549377, 549378, 549441, 549467, 549468, 554 35, 554 36, 554 37, 554 56, 558411, 558412, 558415, A61K 3127, C07C23308

Patent

active

06040339&

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.

REFERENCES:
patent: 4536346 (1985-08-01), Shepherd et al.
patent: 5534529 (1996-07-01), Yoshida et al.
patent: 5614550 (1997-03-01), Yoshida et al.
patent: 5880147 (1999-03-01), Yoshida et al.
Chemical Abstracts, O'Brien et al., "Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase, (ACAT) as Hypocholesterolemic Agents", vol. 121, No. 1, Jul. 4, 1994, Abstract No. 8837r.

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