Uracil reductase inactivators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S049000, C514S050000, C514S256000, C536S028200, C536S028540, C536S028530, C536S028550, C544S309000, C544S313000

Reexamination Certificate

active

07119096

ABSTRACT:
Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4alkyl, C2-6alkenyl, 1-halo-C2-6alkenyl and halo-substituted C2-6alkynyl.

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