Uracil derivatives for use as anti-tumor agents having silicon c

Details Uracil derivatives for use as anti-tumor agents having silicon c Uracil derivatives for use as anti-tumor agents having silicon c

1988-01-04

1989-09-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544229, 544302, A61K 31505, C07F 710, C07D23954

Patent

active

048681890

ABSTRACT:
An organo-silicone compound of the formula ##STR1## wherein X is a methylene or carbonyl radical, Y is an NH or O, n is an integer, R.sub.1 is a hydrogen atom, halogen atom or alkyl group, R.sub.2, R.sub.3 and R.sub.4 are an alkyl group, alkoxy group, phenyl radical or substituted phenyl radical, respectively, and R.sub.5 is a hydrogen atom or a group of ##STR2## in which X, Y, n, R.sub.2, R.sub.3 and R.sub.4 have the meanings as referred to, and used as an anti-tumor agent or for use in anti-tumor compositions.

REFERENCES:
patent: 4560679 (1985-12-01), Toyoshima et al.
patent: 4778797 (1988-10-01), Toyoshima et al.
Voronkov, Top Curr. Chem., vol. 84, pp. 77-135, (1979).
Abstract for JP 59/98091, (6/1984).
Abstract for JP 61/65890, (4/1986).
Abstract for JP 62/10094, (1/1987).
Tatsuro et al., Chemical Abstracts, vol. 108, No. 173534, (1988).
Masatoshi et al., Chemical Abstracts, vol. 109, No. 73646, (1988).

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