Ubiquitin conjugating enzymes 8 and 9

Details Ubiquitin conjugating enzymes 8 and 9 Ubiquitin conjugating enzymes 8 and 9

1997-07-22

1999-10-19

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435440, 5303871, 536 232, 536 234, C12N 910, C12N 1500, C07H 2104

Patent

active

059687975

ABSTRACT:
Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

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