Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-06-02
2000-10-03
Bansal, Geetha P.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242361, 4242431, 4242441, 435 691, 435 693, 514 8, 514 12, A61K 39085, A61K 3902, A61K 3909, C12P 2106
Patent
active
06126945&
ABSTRACT:
Staphylococcal enterotoxins obtained by secretion from Staphylococcus aureus, by expression of enterotoxins in other bacteria or cells, or by chemical mutagenic treatment of Staphlococcus aureus strains are used in treatment of cancer as tumoricidal agents. Enterotoxins A, B, C, D, E and toxic shock toxin (TSST-1) can be administered via simple intravenous injection or in the form of adjuvants such as pluronic triblock copolymers. Enterotoxins may also be used ex-vivo to induce mitogenesis, enlarge and enrich a tumoricidal T-cell population. Streptococcus pyrogenic exotoxins which have structural and functional homology to the enterotoxins, are also useful in tumoricidal treatment. Chemically derivatized enterotoxins as well as synthetic or genetically prepared polypeptides having structural homology to the native enterotoxins are also useful in this application.
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Hel
Stone Jay L.
Terman David S.
Bansal Geetha P.
Pharmacia AB
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