Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-11-12
1992-10-20
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
560 53, 549501, 514530, 514531, 514545, A61K 3134, A61K 3122, C07D30742, C07C 69527
Patent
active
051570483
ABSTRACT:
An improved method for the decarbalkoxyation of alkylated .beta.-keto esters to obtain high yields of ketones. In accordance with the method, decarbalkoxylation of alkylated .beta.-keto esters is accomplished by heating the esters in the presence of dilute aqueous alkali and an effective amount of a phase-transfer agent. The method produces commercially practical yields of ketone in a manner which is facile, economical and environmentally safe. Novel methylene-linked pyrethroid ketones produced from the improved method exhibit insecticidal activity against various agricultural pests.
REFERENCES:
patent: 4100297 (1978-07-01), Grandadam et al.
patent: 4206230 (1980-06-01), Paul
patent: 4713392 (1987-12-01), Elliott et al.
A. Krapcho, et al., Tetrahedron Letters, No. 12, "Decarboxylations of Gemihal Diesters . . . " pp. 957-960 (1973).
P. F. Berteau et al., Science, 161, "Pyrethroid-Like Biological Activity Groupings," pp. 1151-1153 (1968).
D. H. Hunter et al., Synthesis, "Synthetic Applications of Crown Ethers; the Malonic Ester Synthesis," pp. 37-39 (1977).
A. Krapcho, Synthesis, "Synthetic Applications of Dealkoxycarboxylations of Malonate Esters," pp. 805-822 (1982).
Brown Richard T.
Mills Frank D.
Mills, Jr. Giles D.
Fado John D.
Hollrah Glennon H.
Russell Mark W.
Sadowski David R.
Silverstein M. Howard
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