Tryptophanyl tRNA synthetase polypeptides of streptococcus

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...

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530300, 530350, 435 4, C12N 900

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06165759&

ABSTRACT:
The invention provides Tryptophanyl tRNA Synthetase polypeptides and DNA (RNA) encoding Tryptophanyl tRNA Synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Tryptophanyl tRNA Synthetase polypeptides to screen for antibacterial compounds.

REFERENCES:
GenBank Accession No. 164236, Nov. 1995.
GenBank Accession No. P00953, Jul. 1986.
Chalker, et al., "Analysis and Toxic Overexpression in Escherichia coliof a Staphyloccocal Gene Encoding Isoleucyl-tRNA Synthetase", Gene, vol. 141, pp. 103-108, Apr. 8, 1994.
Von Der Haar, et al., "Target Directed Drug Synthesis: The Aminoacyl-tRNA Synthetases as Possible Targets", Angewandte Chemie, vol. 20, No. 3, pp. 217-302, Mar., 1981.
Schmidt, et al., "Dominant Lethality by Expression of a Catalytically Incative class I tRNA Synthetase", Proceedings of the National Academy of Sciences USA, vol. 90, pp. 6919-6923, Aug. 1993.
Laske, et al., "Investigations on the Antiproliferative Effects of Amino Acid Antagonists Targeting for Aminoacyl-tRNA Synthetases. Part I. The Anitleukemic Effect", Archiv Der Pharmazie, vol. 322, No. 12, pp. 847-852, Dec. 1989.
Beresten, et al., "Molecular and Cellular Studies of Tryptophanyl-tRNA Synthetase Using Monoclonal Antibodies", European Journal of Biochemistry, vol. 184, pp. 575-581, Oct. 1989 * pp. 577, Col. 1, line 1 Col. 2, line 15; figures 1 and 2. *Use publication date indicated on the patent or published application. 37 CFR 1.98(b).
Hughes, et al., "How does Pseudomonas Fluroescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, vol. 122, No. 2, pp. 322-324, Dec. 29, 1980.
Witty, et al., "Structure-Activity Dependency of New Bacterial Tryptophanyl tRNA Synthetase Inhibitors", Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 12, Jun. 18, 1996.
European Search Report, completed Aug. 27, 1999, from corresponding European Application No. 97307007.1.
Lindler, et al., Molecular Cloning and Characterization of a Streptococcus SanguisDnase necessary for Repair of DNA Damage Induced by UV Light and Methyl Methanesulfonate. Journal of Bacteriology. Jul. 1987, vol. 169: No. 7, pp. 3199-3208, see entire document.
Brakhage, et al., Structure and Nucleotide Sequence of the Bacillus Subtilis Phenylalanyl-tRNA Synthetase Genes. Biochimie. 1990, vol. 72: pp. 725-734, see entire document.
Putzer, et al., Independent Genes for Two Threonyl-tRNA Synthetases in Bacillus Subtilis. Journal of Bacteriology. Aug. 1990, vol. 172: No. 8, pp. 4593-4602, see entire document.
Springer, et al., Genetic Definition of the Translational Operator of the Threonine-t-RNA Ligase Gene in Escherichia Coli. Proc. Natl. Acad. Sci. USA. Jun. 1986, vol. 83: pp. 4384-4388, see entire document.

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