Trypsin-sensitive agent able to reduce PAI-1 and .beta.APP expre

Details Trypsin-sensitive agent able to reduce PAI-1 and .beta.APP expre Trypsin-sensitive agent able to reduce PAI-1 and .beta.APP expre

1993-02-08

1996-01-09

Knudde, Marian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

530827, 530350, 435 701, 435948, C12P 2102, C07K 300

Patent

active

054828384

ABSTRACT:
Purified trypsin-sensitive agent or analog thereof, able to downregulate collagenase, PAI-1 and .beta.APP expression in senescent cells isolatable from culture medium having growing fibroblasts or U937 promyelocytic cells.

REFERENCES:
Sage, H., et al., "J. Cell Biology," vol. 97, Dec. 1988, pp. 1933-1938.
Goldstein, 249 Science 1129-1133, Sep. 7, 1990.
Finlay and Cristofalo, 168 Exp. Cell Res. 191-202, 1987.
Finlay et al, 156 Exp. Cell Res. 462-470, 1985.

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