Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1985-02-11
1988-08-09
Brown, J. R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530300, 530324, 530806, 435 68, 435 70, 935 47, 935 60, 935109, C07K 1300
Patent
active
047629142
ABSTRACT:
The subject invention concerns truncated human IL-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.
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Nature, vol. 312, 1984, pp. 458-462, Lomedico et al.
Dinarello, C. A. (1984), "Interleukin-1 and the Pathogenesis of the Acute-14 Phase Response", New Eng. Journ. Med. 311:1413-1418.
Auron, P. E. et al. (1984) "Nucleotide Sequence of Human Monocyte Interleukin-1 Precursor cDNA", Proc. Natl. Acad. Sci. USA 81:7907-7911.
Auron Philip E.
Dinarello Charles A.
Gehrke Lee
Rich Alexander
Rosenwasser Lanny J.
Brown J. R.
Draper Garnette D.
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