Truncated EGF receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S069100

Reexamination Certificate

active

06946543

ABSTRACT:
The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF-α. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.

REFERENCES:
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patent: 2002/0002276 (2002-01-01), Fitzpatrick et al.
patent: 91/03489 (1991-03-01), None
patent: 99/62955 (1999-09-01), None
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Kohda et al. (Jan. 1993) “A 40-kDa Epidermal Growth Factor/Transforming Growth Factor α-binding Domain Produced by Limited Proteolysis of the Extracellular Domain of the Epidermal Growth Factor Receptor”The Journal of Biological Chemistry268(3):1976-1981.
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Garrett, TPJ et al. (Sep. 2002) “Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor;”Cell110(6):763-773.
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