Triptolide derivatives as immunomodulators and anticancer...

Details Triptolide derivatives as immunomodulators and anticancer... Triptolide derivatives as immunomodulators and anticancer...

2006-08-29

2006-08-29

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S297000

Reexamination Certificate

active

07098348

ABSTRACT:
Compounds having the structure I:are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1together with R2═O (oxo); R2═OH, or, R1and R2together=O (oxo); CR3R5and CR4R6are selected from CH2, CHOH and CROH; at least one of R1, R5and R6is R; and at least one of CR3R5and CR4R6is CH2.

REFERENCES:
patent: 6004999 (1999-12-01), Jung et al.

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