Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-07
2009-10-20
Habte, Kahsay T (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S071000, C544S101000
Reexamination Certificate
active
07605157
ABSTRACT:
The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogens
REFERENCES:
patent: 5011860 (1991-04-01), Blythin et al.
patent: 5847149 (1998-12-01), Fuss et al.
patent: 7208490 (2007-04-01), Barbachyn et al.
patent: WO 02/34753 (2002-05-01), None
patent: WO 03/091252 (2003-11-01), None
patent: WO 2004033449 (2004-04-01), None
Cecil Textbook of Medicine (20th Edition, vol. 2, 1996, pp. 1739-1747).
Tiwari, et al 5-Nitro-4(2)-[Oxo-3H-Quinazolin-3-yl]-benzyideue-mailonylureas as Antibacterial Agents, J. Indian Chem Soc, 1980, pp. 1039-1040, vol. 57/100.
Beke, Gyula, et al., “Syntheis and Stereochemistry of Dispiro Substituted Pyridazines: Application of Ellipticity-Absorbance Ratio Spectra for Proving Enantiomeric Relationship by HPLC-CD/UV Detection”, Chirality, 2002, vol. 14, pp. 365-371.
Csizmadia, Imre G., Journal of Molecular Structure (Theochem), 666, 2003, xii-xiv.
D'Yachenko, E. V., et al., “tert-Amino effect in heterocyclic chemistry. Synthesis of hydrogenated spiro derivatives of quinolines”, Russian Chemical Bulletin, International Edition, Jun. 2004, vol. 53, No. 6, pp. 1240-1247.
Glukhareva, T. V., et al., “Synthesis of Spiro Derivatives of Pyrrolo[1,2-a]Quinoline”, Chemistry of Heterocyclic Compounds, 2002, vol. 38, No. 11, pp. 1426-1427.
Karolyhazy, Laszlo, et al., “Thermochemical study on the ring closure reaction of 5-morpholino-4-vinylpyridazinones by tert-amino effect”, Journal of Molecular Structure (Theochem), 2003, 666-667, pp. 667-680.
L.C. Groenen, et al., “The tertiary amino effect in heterocyclic synthesis: Mechanistic and computational study of the formation of six-membered rings” Tetrahedron 1988:44(14);4637-4644.
W.H.N Nijhuis, et al., “The tert-amino effect in heterocyclic chemistry: synthesis of tetra- and pentacyclic compounds” Recl. Trav. Chim. Pays-Bas 1989:108, 172-178.
V. Ojea, et al., “Synthesis of New Heterotricyclic Compounds Containing the [1,8]Naphthyridine Group by Thermal Isomerization of 2-Dialkylamino-3-vinylpyridines” Synthesis 1991:798-802.
V. Ojea, et al., “Formation of New Heterotetracyclic Compounds by Ring Closure of 2-Amino-3-vinylpyridines” Synthesis 1992:152-157.
H.C. Richards “Oxamniquine: A Drug for the Tropics”, in “The Role of Organic Chemistry in Drug Research” 1985:271-289.
A. Schwartz, et al., “Applications of tert-amino effect and a nitrone-olefin 1,3-dipolar cycloaddition reaction: synthesis of novel angularly annelated diazino heterocycles” Journal of Molecular Structure (Theochem) 2000:528:49-57.
H.-J. Boehm, et al., J. Med. Chem., (2000), 43, 2664-2674.
D. K. Chen, et al., N. Engl. J. Med., (1999), 341(4), 233-239.
I. Chopra et al., JAMA, (1996), 275(5), 401-403.
Database Chemcats Online, Chemical Abstracts Service, May 2003, XP002266425.
U. Gerlach, “Synthesis of Tricyclic Cyano-Substituted Tetrahydroquinolines by Radical Decyanation of Geminal Dinitriles”, Tetrahedron Letters, 36(29), (1995), 5159-5162, XP004027630.
D. M. Gleave et al; “Synthesis and Antibacterial activity of [6,5,5] and [6,6,5] Tricyclic Fused Oxazolidinones”, Bioorganic & Medicinal Chemistry Letters, 8(10), May 1998. 1231-1236, XP004137053.
O. K. Kim, et al., Exp. Opin. Ther. Patents (1998), 8(8), 959-969.
P. Kotilainen, et al., J. Infect. Dis., (1990), 161, 41-44.
A. Maxwell, Trends in Microbiology, (1997), 5(3), 102-109.
A. Maxwell, Mol. Microbiol., (1993), 9(4), 681-686.
W. H. N. Nijhuis et al: “A Novel two-step Synthesis of Hexahydropyrazino [1,2-Alphau]-quinolines”, Synthesis, vol. 7, (1987), 641-645, XP002266422.
Walter H. N. Nijhuis, et al: “Stereochemical Aspects of the tert-Amino effect”, J. Org. Chem., 54(1), 1989, 209-16, XP002266423.
L.L. Silver and A. K. Bostian, Antimicrob. Agents and Chemother., Mar. 1993, 37(3), 377-383.
M. Trucksis, et al., Ann. Intern. Med. (1991), 114(5), 424-426.
Willem Verboom, et al: “tert-Amino effect in Heterocyclic Synthesis”, Journal of Organic Chemistry, (1984), 49(2), 269-276, XP002266421.
CAS Registry No. 728036-02-0, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 727671-74-1. Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 727371-95-1. Jun. 1, 2004, TimTec. Inc.
CAS Registry No. 727371-95-1, Aug. 10, 2004, Chemical Block, Ltd.
CAS Registry No. 727370-53-0, Jul. 1, 2004, TimTec, Inc.
CAS Registry No. 704878-08-0, Jun. 1. 2004, TimTec, Inc.
CAS Reglstry No. 704875-08-0, Aug. 10, 2004, Chemical Block.
CAS Registry No. 704878-08-0, Sep. 17, 2004, lnterchim.
CAS Registry No. 704878-02-4, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 704878-02-4, Sep. 17. 2004, Interchim.
CAS Registry No. 698655-91-0, Sep. 17. 2004, Interchim.
CAS Registry No. 698658-91-0, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 696630-59-8, Jan. 1, 2004, Ambinter.
CAS Registry No. 696620-59-8, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 896630-59-8, Sep. 17, 2004, lnterchim.
CAS Registry No. 695220-71-4, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 695220-71-4, Sep. 17, 2004, lnterchim.
CAS Registry No. 695211-59-7, Jan. 1, 2004, Ambinter.
CAS Registry No. 695211-59-7, Jun. 1, 2004, TimTec, Inc.
CAS Registry No. 695211-59-7, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 695211-59-7, Sep. 17, 2004. Interchim.
CAS Registry No. 695211-58-8, Jan. 1, 2004, Ambinter.
CAS Registry No. 695211-58-6, Jun. 1, 2004, TimTec, Inc.
CAS Registry No. 695211-58-6, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 695211-58-6, Sep. 17, 2004, Interchim.
CAS Registry No. 695202-34-7, Jan. 1, 2004, Ambinter.
CAS Registry No. 695202-34-7, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 695202-34-7, Sep. 17, 2004, Interchim.
CAS Registry No. 695202-34-7, Jun. 1, 2004, TimTec, Inc.
CAS Registry No. 663946-83-6, Mar. 1, 2005, SPECS.
CAS Registry No. 401608-21-7, May 16, 2005, Labo Test.
CAS Registry No. 346630-58-6, retrieved from database 2005.
CAS Registry No. 296244-43-4, Apr. 25, 2003, ChemDiv, Inc.
CAS Registry No. 296244-43-4, Aug. 11, 2003, Zetinsky Institute of Organic Chemistry.
CAS Registry No. 296244-43-4, Jan. 1, 2004, Ambinter.
CAS Registry No. 296244-43-4, Jun. 1. 2004, TimTec, Inc.
CAS Registry No. 296244-43-4, Aug. 10, 2004, Chemical Block Ltd.
CAS Registry No. 296244-43-4, Sep. 17, 2004, Interchim.
CAS Registry No. 296244-43-4, Feb. 21, 2005, AsinEx.
Declaration of Alexander R. Hurd including Exhibits I and II. Jun. 2005 (exhibits I and II, 2002).
PCT international Search Report: PCT/IB 03/004389, Apr. 15, 2004.
Joyeau et al.,“Synthesis of Benzocarbacephem and Benzocarbapenem Derivatives by Copper-promoted Intermolecular Aromatic Substitution”, Chem. Soc. Perkin Trans 1987 pp. 1899-1907.
Verboom et al.,. “‘tert-Amino Effect’ in Heterocyclic Synthesis. Formation of N-Heterocycles by Ring-Closure Reactions of Substituted 2-Vinyl-N, N-dialkylanilines”, J. Org. Chem. 1984, 49, 269-276.
Barbachyn Michael Robert
Dobrowolski Paul Joseph
Hurd Alexander Ross
McNamara Dennis Joseph
Palmer John Raymond
Benson Gregg C.
Habte Kahsay T
Pharmacia & Upjohn Company LLC
Tebbutt Jason G.
LandOfFree
Tricyclic tetrahydroquinoline antibacterial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tricyclic tetrahydroquinoline antibacterial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic tetrahydroquinoline antibacterial agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4126739