Tricyclic modulators of the glucocorticoid receptor, AP-1,...

Details Tricyclic modulators of the glucocorticoid receptor, AP-1,... Tricyclic modulators of the glucocorticoid receptor, AP-1,...

2007-07-05

2009-06-09

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S233000, C548S265400, C548S332500, C514S371000, C514S377000, C514S383000, C514S398000

Reexamination Certificate

active

07544808

ABSTRACT:
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I)or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein B, J, K, Z, R, Ra, Rb, Rc, Rd, Rq, Rw, m and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

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