Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-11-16
1993-02-23
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514214, 514305, 514213, 514291, 514292, 514299, 540484, 540552, 546 86, 546 89, 546 66, A61K 3144, C07D47102, C07D23300
Patent
active
051890410
ABSTRACT:
5-HT.sub.3 receptor antagonist compounds of the formula ##STR1## in which Z is --O--, --S-- or --N(R.sup.2)--; R.sup.1 and R.sup.2 are independently selected from hydrogen and lower alkyl or are together --(CH.sub.2).sub.n -- wherein n is 2 to 4; and R.sup.3 is selected from ##STR2## and the pharmaceutically acceptable salts, individual isomers, compositions, and methods of use thereof.
REFERENCES:
patent: 4218453 (1980-08-01), Hannart
patent: 5013733 (1991-05-01), Coates et al.
The Lancet, Sep. 23, 1989, p. 717.
J. Pharmacol. Exp. Ther., 1988, 245, 773.
Trends Pharmacol. Sci., 1988, 9, 141.
Gastroenterology Clinics of North America, 1989, 18, 437.
Berger Jacob
Clark Robin D.
Freyberg Derek P.
Kumar Shailendra
Montgomery Wayne W.
Moran Tom M.
Raymond Richard L.
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