Triazole derivatives as tachykinin receptor antagonists

Details Triazole derivatives as tachykinin receptor antagonists Triazole derivatives as tachykinin receptor antagonists

2008-01-22

2008-01-22

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S255000

Reexamination Certificate

active

10512249

ABSTRACT:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3alkane-diyl; R1is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4alkyl, C1-C4alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)

REFERENCES:
patent: 5998444 (1999-12-01), Russell
patent: 6060478 (2000-05-01), Gilligan et al.
patent: 6407106 (2002-06-01), Jasserand et al.
patent: 7179804 (2007-02-01), Amegadzie et al.
patent: 0 699 665 (1996-03-01), None
patent: 0 699 665 (2003-05-01), None
patent: 2 329 275 (1976-10-01), None
patent: P2002-123925 (2002-04-01), None
patent: WO 95/11880 (1995-05-01), None
patent: WO 97/40025 (1997-10-01), None
patent: WO 98/03510 (1998-01-01), None
patent: WO 99/07677 (1999-02-01), None
patent: WO 01/44200 (2001-06-01), None
patent: WO 02/08232 (2003-01-01), None
Duffy et al., Correlation of NK-1 receptor occupancy in gerbil striatum with behavorial effects of NK1 antagonists, J. Pharm. And Ex. Th., vol. 301, No. 2, 2002, especially pp. 536-542.
L'Abbé, et al., “Synthesis and Thermolysis of 4-Substituted 5-Azido-1-Phenyl-1,2,3- Triazoles”,Tetrahedron, 44:12, pp. 3617-3626 (1988).
Hajjaji, et al., “Synthesis and Evaluation of the Inhibitor Effect of a New Class of Triazole Compounds,”Progress in Organic Coatings, 38, pp. 207-212 (2000).
Abu-Orabi, et al., “Dipolar Cycloaddition Reactions of Organic Azides,”J. Heterocyclic Chem., 26, pp. 1461-1468 (1989).
Theocharis, et al., “Synthesis and Spectral Data of 4,5-Bix[5-aryl-1,3,4- oxadiazol-2-yl]-1-benzyl-1,2,3-triazoles,”J. Heterocyclic Chem, 27, pp. 1685-1688 (1990).
Al-Talib, et al., “Synthesis of 4,5-Bis-[5-aryl-1,3,4-oxadiazol-2-YL]-1-Substgituted Benzyl-1,2,3-Triazoles,”Indian J. of Heterocyclic Chem., 8, pp. 183-188 (1999).
Cottrell, “An Improved Procedure for the Preparation of 1-Benzyl-1H-1,2,3- triazoles from Benzyl Azides,”J. Heterocyclic Chem., 28, pp. 301-304 (1990).
ACS Chemcats 2001:1613994, Publication Date Jan. 7, 2001, Order No. AN-666/14744011, CAS Registry No. 354780-46-4.
Biagi, et al., “N<6>-Cycloalkyl-2-Phenyl-3-Deaza-8-Azaad Nines: A New Class of A1 Adenosine Receptor Ligands. A Comparison With the Corresponding Adenines and 8-Azaadenines”,European J. of Medicinal Chemistry, 38, pp. 983-990 (2003).
Ivanov, et al., “Synthesis of 1,2,3-Triazolo '5,4-e!-1,4-diazepine”,J. of Organic Chemistry of the USSR, XP009037402, 25:9, pp. 1785-1789 (1989).
Katritzky, et al., “Synthesis of C-Carbamoyl-1,2,3-triazoles by Microwave-Induced 1,3-Dipolar Cycloaddition of Organic Azides to Acetylenic Amides”,J. Organ. Chem., XP002299474, 67, pp. 9077-9079 (2002).
Katritzky, et al., “1,3-Dipolar Cycloadditions of Organic Azides to Ester or Benzotriazolylcarbonyl Activated Acetylenic Amides”,ARKIVOC, 15, XP002299475, 15, pp. 47-64 (2003).

Affiliated with

Also associated with

Rating

Triazole derivatives as tachykinin receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triazole derivatives as tachykinin receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triazole derivatives as tachykinin receptor antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3957159