Triacetin as a penetration enhancer for transdermal delivery of

Details Triacetin as a penetration enhancer for transdermal delivery of Triacetin as a penetration enhancer for transdermal delivery of

1997-01-03

1998-11-10

Brouillette, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 514946, A61F 1302

Patent

active

058340106

ABSTRACT:
A composition and method for enhancing transdermal penetration of a basic drug are described. The composition comprises a matrix patch comprising an effective amount of a basic drug, preferably having a pK.sub.a of about 8.0 or greater, an effective amount of a penetration enhancer consisting essentially of triacetin, and a polymer layer preferably comprising a pressure-sensitive adhesive. A preferred basic drug is oxybutynin and acid addition salts thereof. The method for enhancing transdermal penetration comprises applying the matrix patch to a selected area of skin.

REFERENCES:
patent: 4414222 (1983-11-01), Brooker
patent: 4666926 (1987-05-01), Mahjour
patent: 4789547 (1988-12-01), Song
patent: 4814173 (1989-03-01), Song
patent: 4875313 (1989-10-01), Song
patent: 4879297 (1989-11-01), Mahjour
patent: 4895727 (1990-01-01), Allen
patent: 4908389 (1990-03-01), Mahjour
patent: 5019395 (1991-05-01), Mahjour
patent: 5186938 (1993-02-01), Sablotsky
patent: 5214030 (1993-05-01), Stief
patent: 5482970 (1996-01-01), Kim

Affiliated with

Also associated with

Rating

Triacetin as a penetration enhancer for transdermal delivery of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Triacetin as a penetration enhancer for transdermal delivery of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Triacetin as a penetration enhancer for transdermal delivery of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1514239