Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-05
1999-01-12
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 43525411, 4353201, 435325, 435183, 536 232, C12N 1552, C12N 1563
Patent
active
058587055
ABSTRACT:
A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.
REFERENCES:
Tomkinson et al. DNA ligase III is the major high molecular weight DNA joining activity in SV40-transformed human fibroblasts: normal levels of DNA ligase III activity in Bloom syndrome cells. Nucleic Acids Research. vol. 21, No. 23, pp. 5425-5430, Nov. 25, 1993.
Caldecott et al. An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Molecular and Cellular Biology. vol. 14, pp. 68-76, Jan. 1994.
Tomkinson et al. Three distinct DNA ligases in mammalian cells. The Journal of Biological Chemistry. vol. 266, No. 32, pp. 21728-21735, Nov. 15, 1991.
Auffray et al. Partial cDNA sequence in EST-STS database, Accession No. Z45685, Nov. 6, 1994.
Auffray et al. Partial cDNA sequence in EST-STS database, Accession No. T95824, Mar. 27, 1995.
Auffray et al. Partial cDNA sequence in EST-STS database, Accession No. D15404, Mar. 18, 1995.
Auffray et al. Partial cDNA sequence in EST-STS database, Accession No. F07530, Feb. 17, 1995.
Auffray et al. Partial cDNA sequence in STS-EST database, Accession No. F00233, Mar. 7, 1995.
Hillier et al. Partial cDNA sequence in STS-EST database, Accession No. T95919, Mar. 27, 1995.
Clark et al. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. Molecular Biology of the Cell. vol. 5, No. 12, pp. 1301-1310, Dec. 1994.
Haseltine William A.
Wei Ying-Fei
Yu Guo-Liang
Human Genome Sciences Inc.
Lathrop Brian
Mullins J. G.
Olstein Elliot M.
Walsh Stephen
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