Tri-substituted ureas as cytokine inhibitors

Details Tri-substituted ureas as cytokine inhibitors Tri-substituted ureas as cytokine inhibitors

2005-04-21

2008-11-11

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S323000

Reexamination Certificate

active

07449474

ABSTRACT:
The present invention relates to 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1,1,3-tri-substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

REFERENCES:
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Holzheimer, PubMed Abstract (J Chemother. 13 Spec No. 1(1): 159-72), 2001.
Lesher, George Y., et al., “Novel orally active inhibitors of passive cutaneous anaphylaxis in rats: N-[2-(4-pyridinyl)-4-pyrimidinyl]ureas and dialkyl[[[2-(4-pyridinyl)-4-pyrimidinyl]amino]methyler,” Journal of Medical Chemistry, 25(7), 837-42. 1982, p. 841; Table IV.

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