Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-05
2000-11-28
Swartz, Rodney P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4242411, 4242421, 4242571, 435 737, 435849, A61K 3902, A61K 39108, G01N 33569, C12N 100
Patent
active
061533963
ABSTRACT:
Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.
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Willems, Rob J. L. et a
Harris Mark
Hultgren Scott
Jones Charles Hal
Kihlberg Jan
Kuehn Meta
Siga Pharmaceuticals, Inc.
Swartz Rodney P.
Washington University
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