Treatment of sepsis-induced acute renal failure

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 31415

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active

058497749

ABSTRACT:
Methods are provided for treating sepsis/endotoxin-induced acute renal failure, and renal vasoconstriction and catecholamine-induced renal and mesenteric vasconstriction by administering to a patient a therapeutically effective amount of a composition comprising at least one drug with Type IV phosphodiesterase inhibiting activity or any combination thereof and a pharmaceutically acceptable carrier.

REFERENCES:
Beavo, J.A., et al., Mol. Pharmacol. 46:399 (1994):.
Beavo, J.A., et al., TIPS 11:150 (1990).
Morrison, D.C.,, et al., Annu. Rev. Med. 38:416 (1987).
Turney, J.H., et al., Q.J. Med. 74:83 (1990).
Brackeen, M.F., et al., J. Med. Chem. 38:4848 (1995).
Stafford, J.E., et al., J. Med. Chem. 38:4972 (1995).
Heaslip, R.J., et al., J. Pharmacol. Exp. Ther. 268:888 (1994).
Ashton, M.J., et al., J. Med. Chem. 37:1696 (1994).
Verghese, M.W., et al., J. Pharmacol. Exp. Ther. 272:1313 (1995).
Feldman, P.L., et al., J. Med. Chem. 38:1505 (1995).
Landow, L., et al., Acta Anaesths. Scand. 38(7):626 (1994).
Liu, P., et al., Shock 3(1):56 (1995).
Kambayashi, T., et al., J. Immun. 155:4909 (1995).
Sekut, L., et al., Clin. Exp. Immunol. 100(1):126 (1995).
Dent, G., et al., J. Pharmacol. Exp. Ther. 271:1167 (1997).
Chini, C., et al., Kidney Int. 46:28 (1994).
Fisher, W., et al., Biochem. Pharmacol. 45:2399 (1993).
Cardelus, I., et al., E.J. Pharmacol. 299:153 (1996).
HCAPLUS abstract, AN 1996:435288, Begany et al. (1996).
HCAPLUS abstract, AN 1973:67018, Hamilton (1972).
HCAPLUS abstract, AN 1994:236189, Stief et al., (DE 4230755), 1994.

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