Poly(vinyl alcohol) cryogel

Details Poly(vinyl alcohol) cryogel Poly(vinyl alcohol) cryogel

1997-09-17

1999-11-09

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623901, 602 49, A61F 202, A61F 1300

Patent

active

059818263

ABSTRACT:
The present invention includes a poly(vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. A process in connection with the present invention eliminates any step involved with dehydration of the hydrogel prior to implantation thereof. The hydrogel construct may include a tissue scaffolding, a load bearing surface within a joint, or any other structure which is suitable for supporting the growth of tissue.

REFERENCES:
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patent: 5512475 (1996-04-01), Naughton et al.
Study of cryostructurization of polymer systems, Colloid & Polymer Science, v. 264, pp. 19-24 (1986); V.I. Lozinsky, E.S. Vainerman, L. V. Domotenko, A.M. Mamtsis, E.F. Titova, E.M. Belavtseva, and S.V. Rogozhin.
Thermal and rheological properties of poly (vinyl alcohol) hydrogels prepared by repeat cycles of freezing and thawing, Makromol. Chem., v. 189, pp. 871-880 (1988); Mimeo Watase, Katsuyoshi Nishinari.
Polyvinyl Alcohol Cryogel: An Ideal Phantom Material for MR Studies of Arterial Flow and Elasticity, Magnetic Resonance in Medicine, v. 37, pp. 314-319 (1997); Kenneth C. Chu, Brian K. Rutt.
Poly (vinyl alcohol) hydrogels prepared by freezing--thawing cyclic processing, Polymer, v. 33, pp. 3932-3936 (1992); Shauna R. Stauffer and Nikolaos A. Peppas.

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