Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1986-12-17
1991-09-10
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514823, 514922, A61K 4900
Patent
active
050472291
ABSTRACT:
Calcium modulators can be effectively used to treat cardiovascular and cerebral toxicity induced by materials that alter the normal interaction of neurotransmitters with the calcium transport mechanisms of myocardial and cerebral cells. For example, calcium modulators can be used as an antidote to the lethal and chronic toxicity of cocaine and related indirectly acting sympathomimetic amines, imipramine and other tricyclic antidepressants, ganglionic stimulating drugs, and other toxic substances such as organophosphorus compounds that cause accumulations of neurotransmitters. Calcium modulators can also be used as an antidote to substances whose toxicity is based upon anticholinesterase activity. In addition, calcium modulators can be used as antagonists to the various types of toxic substances.
REFERENCES:
Godfraind et al., "Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions", pp. 1-322, Nijhoff Nahas et al., Chem. Abst., 105(1):528q (1986).
Fiedler et al., Chem. Abst., 103(17):134856n (1985).
Sato et al., Chem. Abst., 98(17):137409h (1983).
The Merck Index, 10th Ed., (1983), p. 318, No. 2217.
The Merck Index, 10th Ed., (1983), p. 489, No. 3366.
Nahas et al., (Nahas), The New England Journal of Medicine, "A Calcium-Channel Blocker as Antidote to the Cardiac Effects of Cocaine Intoxication", vol. 313, No. 8, Aug. 22, 1985, pp. 519-520.
Federation Proceedings, 45, Mar. 5, 1986, p. 1063, "Calcium Antagonists (5284-5289)", Nos. 5284-5289.
A. Fleckenstein, "Calcium Antagonism in the Heart and Smooth Muscle", John Wiley & Sons, New York, pp. 1-399, 1983.
T. Godfraind, A. G. Herman, D. Wellens, "Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions", pp. 1-322, Martinus Nijhoff, Boston, 1984.
Nahas Gabriel G.
Trouve Renaud
Friedman Stanley J.
Miles Inc.
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