Transistor-based apparatus and method for molecular detection an

Details Transistor-based apparatus and method for molecular detection an Transistor-based apparatus and method for molecular detection an

1996-08-20

1998-10-27

Jones, W. Gary

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

435 6, 435 71, 435 79, 435 4, 204400, 204403, 204456, 436518, 422 50, 422 681, 422 76, 422 8201, 422 8205, G01N 2702, G01N 2726, G01N 3353, C12Q 168

Patent

active

058274820

ABSTRACT:
Binding of a molecule to a molecular receptor is sensed using a transistor having a gate located at a binding site. The channel conductance of the transistor is modified by a charge associated with the molecule when the molecule binds with the molecular receptor. A modified electrical characteristic of the transistor which results is sensed to sense the binding event. Electric field enhancement is provided by applying a voltage to the gate. A second sensing transistor can be coupled to the sensing transistor to form a differential pair. The differential pair allows for enhancing and sensing of differential binding events.

REFERENCES:
patent: 4490216 (1984-12-01), McConnell
patent: 5074977 (1991-12-01), Cheung et al.
patent: 5466348 (1995-11-01), Holm Kennedy
patent: 5495184 (1996-02-01), Des Rosiers et al.
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5653939 (1997-08-01), Hollis et al.
Storey, In ElectronicsL A Systems Apporpachpages 176-177, 1992.

Affiliated with

Also associated with

Rating

Transistor-based apparatus and method for molecular detection an does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transistor-based apparatus and method for molecular detection an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transistor-based apparatus and method for molecular detection an will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1611824