Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-10-03
2006-10-03
Priebe, Scott D. (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
Reexamination Certificate
active
07115796
ABSTRACT:
The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplantation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.
REFERENCES:
Cozzi, Nature Medicine, 1:964-966, 1995.
Zhang, Exp. Opin. Invest. Drugs, 9:2051-2068,2000.
Kuwaki, Nature Medicine, 11:29-31, 2005.
Rohde, Genes and Development, 19:570-582, 2005.
Kappel, Current Biology, 3:548-553, 1992.
Williams and Wagner, J. Appl. Physiol., 88:1119-1126, 2000.
Niemann, 1997, Transg. Res. 7:73-75.
Haase, I., Journal of Dermatology, 31:704-719, 2004.
Murphy, L.J and Silha,J.V., Growth Hormone and IGF Research, 10:233-235, 2000.
Kiang, J.G., et al., “Heat Shock Protein 70 kDa: Molecular Biology, Biochemistry, and Physiology”Pharmacol. Ther., 80(2):183-201, 1998.
Marber, M.S., et al., “Overexpression of the Rat Inducible 70-kD Heat Stress Protein in a Transgenic Mouse Increases the Resistance of the Heart to Ischemic Injury”,J. Clin. Invest, 95: 1446-1456, Apr. 1995.
Mirkes, P.E., et al., “Heat Shock Protein 70 (Hsp70) Protects Postimplantation Murine Embryos From the Embryolethal Effects fo Hypertherthermia”Developmental Dynamics214: 159-170, 1999.
Plumier, J.C. et al., “Transgenic Mice Expressing the Human Heat Shock Protein 70 Have Improved Post-Ischemic Myocardial Recovery”,J. Clin. Invest., 95: 1854-1860, Apr. 1995.
Chen, Ming-Yu, Partial Abstracts of the 5thConference of the Asia-Pacific International Molecular Biology Network (A-IMBN)(Part 1): Augmentation of thermotolerance in primary skin fibroblasts from a transgenic pig overexpressing the porcine HSP70.2,Acta Biochimica et Biophysica Sinica35(2): 198, 2003.
Chen, Ming-Yu, “Augmentation of thermotolerance in primary skin fibroblasts from a transgenic pig overexpressing the porcine HSP70.2”,Asian-Australia Journal of Animal Sciences, 18(1): 107-112, 2005.
Chen Ming-Yu
Huang San-Yuan
Lee Wen-Chuan
Lin Jyh-Hung
Tu Ching-Fu
Animal Technology Institute
Bertoglio Valarie
Priebe Scott D.
Rothwell, Figg Ernst & Manbeck, PC
LandOfFree
Transgenic pig containing heat shock protein 70 transgene does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Transgenic pig containing heat shock protein 70 transgene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic pig containing heat shock protein 70 transgene will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3626068