Transformed yeast cells expressing heterologous G-protein couple

Details Transformed yeast cells expressing heterologous G-protein couple Transformed yeast cells expressing heterologous G-protein couple

1994-02-14

1997-11-25

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

435 691, 43525421, 4353201, 536 231, C12N 1581

Patent

active

056911882

ABSTRACT:
A first aspect of the present invention is directed to a transformed yeast cell containing a first heterologous DNA sequence which codes for a G protein-coupled receptor, for example, the somatostatin receptor, and a second heterologous DNA sequence which codes for a G protein .alpha. subunit or portions thereof fused to DNA sequences from the yeast G protein a subunit. A second aspect of the present invention is a transformed yeast cell containing a heterologous DNA sequence which codes for a G protein coupled receptor. A third aspect of the present invention is a method of assaying compounds to determine effects on cell growth.

REFERENCES:
patent: 5284746 (1994-02-01), Sledziewski
Dohlman, et al., Model Systems for the Study of Seven-Transmembrane-segment Receptors, vol. 60, pp. 653-688, Annu. Rev. Biochem, 1991.
Sprague et al., The Molecular Cellular Biology of the Yeast Sacchromyces cerevisiae; Gene Expression, vol. II, pp. 657-643 1992, Cold Spring Harbor .

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