Transformed industrial bacillus strains and methods for making a

Details Transformed industrial bacillus strains and methods for making a Transformed industrial bacillus strains and methods for making a

1996-08-16

1998-02-10

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435202, 435212, 4351723, 43525231, C12P 2102, C12N 928, C12N 948, C12N 121

Patent

active

057168075

ABSTRACT:
Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide of interest are introduced into a compatible host. Transformed hosts harboring the introduced vehicle in a stable way by integration of the vehicle into the host cells chromosome are selected. Efficient transfer of the vehicle containing the gene of interest is achieved, with the resulting industrial strain transformants being effective, stable producers of the desired polypeptide product.

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Wesseling, Developments in Industrial Microbiology (1982) 23: 31-40, Soc. For Indust. Microbiol., Annadale, VA.
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