Toso as a target for drug screening

Details Toso as a target for drug screening Toso as a target for drug screening

2005-02-15

2005-02-15

Brumback, Brenda (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007210, C435S069100, C435S070100, C536S023100, C536S024300

Reexamination Certificate

active

06855495

ABSTRACT:
The present invention is directed to methods for identifying novel compositions which modulate the activity of Toso, and the use of such compositions in diagnosis and treatment of disease.

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Hitoshi et al., “Toso, a Cell-Surface Specific Regulator of Fas-Induced Apoptosis in T Cells,” U.S. Appl. No. 60/066,063, filed Nov. 17, 1997.
Hitoshi et al., “Toso, a Cell-Surface Specific Regulator of Fas-Induced Apoptosis in T Cells,” Immunity, 8:461-471 (1998).
Rothenburg et al., “Intracellular Combinatorial Chemistry with Peptides in Selection of Caspase-Like Inhibitors,” Nato Advanced Science Institutes, Series H: Cell Biology, H105:171-183 (1998).
Hitoshi, Y. et al., “Retroviral Approach to Isolate Molecules that Regulate-FAS-Induced Apoptosis in T cells,” Meeting Abstract. CSH Laboratory meeting, Sep. 1997. Programmed Cell Death segment.

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