Topical oil-in-water emulsions containing retinoids

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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424450, 424 59, 424 60, 424 7803, 424 7805, 424 7806, 424 7807, 424DIG13, 424DIG14, 514859, 514887, 514937, 514938, 514944, A61K 3107, A61K 9107

Patent

active

059765550

ABSTRACT:
Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability. More particularly, said skin care compositions contain (a) an emulsifier system selected from the group consisting of: (i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate; (ii) cetearyl alcohol and cetearyl glucoside; (iii) a mixture of a polyethylene glycol ethers of stearyl alcohol; and (iv) a mixture of sorbitan stearate and polysorbate 60; (b) a co-emulsifier selected from the group consisting of cetyl alcohol, stearyl alcohol and mixtures thereof; (c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition which contains (i) a light, dry absorbable oil and (ii) substantive, emollient oils or waxes, wherein the light, dry absorbable oil and the substantive oil or wax are present in a ratio of from about 1:3 for about 10:1.

REFERENCES:
patent: 4247547 (1981-01-01), Marks
patent: 4333924 (1982-06-01), Bowley et al.
patent: 4595586 (1986-06-01), Flom
patent: 4603146 (1986-07-01), Kligman
patent: 4826828 (1989-05-01), Wilmott et al.
patent: 5391373 (1995-02-01), Mausner

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