Tissue specific fluorescent chelates possessing long...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence

Reexamination Certificate

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C424S001110, C424S001650, C424S009100, C424S009300, C424S009362, C424S009700, C424S009800, C534S014000, C540S450000, C540S460000, C540S474000

Reexamination Certificate

active

06962690

ABSTRACT:
Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents for soft tissue cancers.

REFERENCES:
patent: 4920195 (1990-04-01), Kankare et al.
patent: 4976950 (1990-12-01), Simon et al.
patent: 5312922 (1994-05-01), Diamandis
patent: 5928627 (1999-07-01), Kiefer et al.
patent: 2003/0129579 (2003-07-01), Bornhop et al.
patent: WO 94/26275 (1994-11-01), None
patent: WO 94/26753 (1994-11-01), None
patent: WO 97/40055 (1997-10-01), None
Griffin, J. M. M., et al, “Simple, high yielding synthesis of trifunctional fluorescent lanthanide chelates”,Tetrahedron Letters42 (2001) 3823-3825.
Baden, E. “Prevention of Cancer of the Oral Cavity and Pharynx,”CA Cancer Journal for Clinicians, vol. 31, No. 1, 1987, pp. 49-62.
Cacheris, W. P. et al., “Thermodynamic study of Lanthanide Complexes of 1,4,7-Triazacyclononane-N,N′N′′-triacetic Acid and 1,4,7,10-Tetraazacyclododecane-N.,N′,N′′,N′′′-tetraacetic Acid,”Inorganic Chem, vol. 26, 1987, pp. 958-960.
Devoisselle, J. M. et al., “Measurement of in vivo fumorous
ormal tissue pH by localized spectroscpy using a fluorescent marker,”Optical Engineering, vol. 32, No. 2 193, pp. 239-243.
Diamandis, E. P and Christopoulos, T. K., “Europium Chelate labels in Time-Resolved Fluorescence Immunoassays and DNA Hybridization Assays,”Analytical Chemistry, vol. 62, No. 22, 1990, pp. 1149A-1157A.
Diamandis, E. P., “Immunoassays with Time-Resolved Fluorescence Spectrscopy: Principles and Applications,”Clinical Biochemistryvol. 21, Jun. 1988, pp. 139-150.
Diamandis, E. P., Analytical Methodology for Immunoassays and DNA Hybridization Assays-Current Status and Selected Systems-Critical ReviewClinica Chimica Acta., vol. 194, 1990, pp. 19-50.
Griffin, J. M. M. et al., “Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates,”Tetrahedron Letters, vol. 42, 2001, pp. 1-3.
Gross, D. J., “Quantitative Single Cell Fluorescence Imaging of Indicator Dyes,”Noninvasive Techniques in Cell Biology, Wiley-Liss Publishers, New York, NY, 1990, Chap. 2, pp. 21-51.
Haugland, R. P. and Minta, A., “Design and Application of Indicator Dyes,”Noninvasive Techniques in Cell Biology, Wiley-Liss Publishers, New York, NY, 1990, Chap. 1, pp. 1-20.
Kallistratos, G., “Fluorescent Properties of Aromatic Complexes with Rare Earths and Other Elements of the IIIa Group,”Chemika Chronika, New Series, vol. 11, 1982, pp. 249-266.
Kim, W. D., et al., “Relaxometry, Luminescence Measurements, Electrophoresis, and Animal Biodistribution of Lanthanide (III) Complexes of Some Polyaza Macrocyclic Acetates Containing Pyridine,”Inorganic Chem., vol. 34, 1995, p. 2233-2243.
Latva, M. et al., “Correlation Between the Lowest Triplet State Energy Level of the Ligand and Lanthanid (III) Luminescence Quantum Yield,”Journal of Luminescence, vol. 75, 1994, pp. 149-169.
Marks, P. H. and Schechter, F. G., “Multiple Primary Carcinomas of the Hand, Neck, and Lung,”The Annals of Thorac Surgeryvol. 33, No. 4, Apr. 1982, pp. 324-332.
Silverman Jr., S. and Gorsky, M., “Epidemiologic and Demographic Update in Oral Cancer: California and National Data 1973-1985,”Journal of Am. Dent. Assoc. vol. 120 No. 5, May 1990 pp. 495-499.
Soini, E. and Lovgren, T., “Time-Resolved Fluoescence of Lanthanide Probes and Applications in Biotechnology,”Crit. Rev. Anal. Chem. vol. 18, 1987, pp. 105-154.
Varbec, D. P., “Multiple Primary Malignancies Associated with Index Cancers of the Oral, Pharyngeal and Laryngeal Areas,”Trans. Pa. Acad. Opthalmol. Otolaryngol., vol. 32 No. 2, 1979, pp. 177-181.

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