Tissue-specific enhancer active in prostate

Details Tissue-specific enhancer active in prostate Tissue-specific enhancer active in prostate

1995-01-30

1997-07-15

Stone, Jacqueline M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4353201, C07H 2104, C12N 1563

Patent

active

056484780

ABSTRACT:
The invention provides a human prostate-specific transcriptional regulatory sequence, polynucleotide comprising such regulatory regions, toxin gene constructs wherein a toxin gene is expressed under the transcriptional control of a human prostate-specific transcriptional regulatory sequence, and methods for treating prostate disease using such toxin gene constructs.

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Henttu, et al., cDNA Coding for the Entire Human Prostate Specific Antigen Shows High Homologies to the Human Tissue Kallikrein Genes (Apr. 28, 1989) Biochemical and Biophysical Research Communications, pp. 903-910.
Lundwall, Characterization of the Gene for Prostate-Specific Antigen, A Human Gladnular Kallikrein (Jun. 30, 1989) Biochemical and Biophysical Research Communications, pp. 1151-1159.
Young, et al., Tissue-Specific and Hormonal Regulation of Human Prostate-Specific Glandular Kallikrein (1992) Biochemistry 31:818-824.
Wolf, et al., Transcriptional Regulation of Prostate Kallikrein-Like Genes by Androgen (1992) Molecular Endocrinology, pp. 753-762/.

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