Tissue plasminogen activator analogs having modified growth fact

Details Tissue plasminogen activator analogs having modified growth fact Tissue plasminogen activator analogs having modified growth fact

1995-03-06

1996-01-23

Fleisher, Mindy B.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

124 9464, 435 712, 4352402, 4352523, 43525231, 43525233, 43525411, 43525421, 4352543, 4353201, 536 232, C12N 964, C12N 121, C12N 510, A61K 3849

Patent

active

054864712

ABSTRACT:
Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along With a physiologically acceptable carrier or diluent are also disclosed.

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patent: 4916071 (1990-04-01), Hung et al.
patent: 4959314 (1990-09-01), Mark et al.
van Zonneveld et al, Proc. Natl Acad Sci, USA, vol. 83, pp. 4670-4674, Jul. 1986.
Ny et al, Proc. Natl. Acad Sci, vol. 81, pp. 5355-5359, 1984.
Wang, et al, Science, vol. 224, pp. 1431-1433, 1984.

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