Time-specific controlled release dosage formulations and method

Details Time-specific controlled release dosage formulations and method Time-specific controlled release dosage formulations and method

1997-01-29

1999-04-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424480, A61K 916, A61K 950

Patent

active

058914749

ABSTRACT:
The present invention provides a method of achieving the time-specific delivery of a pharmaceutically active agent to a patient in need of the therapeutic effects of the pharmaceutically active agent. The method includes administering a pharmaceutical formulation comprising (a) a core including the pharmaceutically active agent to be delivered, and (b) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer. The swellable polymeric coating layer surrounding the core is provided by a new method which includes alternately (i) wetting the core with a binder solution, and (ii) coating the core with powdered polymeric particles a sufficient number of times to produce a time-specific dosage formulation having the desired thickness of swellable polymeric coating layer.

REFERENCES:
patent: 3131123 (1964-04-01), Masquelier
patent: 4035899 (1977-07-01), Saeki et al.
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4713248 (1987-12-01), Kj.o slashed.rn es et al.
patent: 4780318 (1988-10-01), Appelgren et al.
patent: 4786505 (1988-11-01), Lovgren et al.
patent: 4786506 (1988-11-01), Fontanelli
patent: 4844905 (1989-07-01), Ichikawa et al.
patent: 4851231 (1989-07-01), Urquhart et al.
patent: 4853230 (1989-08-01), Lovgren et al.
patent: 4853249 (1989-08-01), Takashima et al.
patent: 4857337 (1989-08-01), Miller et al.
patent: 4863742 (1989-09-01), Panoz et al.
patent: 4871549 (1989-10-01), Ueda et al.
patent: 4882169 (1989-11-01), Ventouras
patent: 4886669 (1989-12-01), Ventouras
patent: 4888179 (1989-12-01), Appelgren et al.
patent: 4910021 (1990-03-01), Davis et al.
patent: 4971805 (1990-11-01), Kitanishi et al.
patent: 5007790 (1991-04-01), Shell
patent: 5084278 (1992-01-01), Mehta
patent: 5096717 (1992-03-01), Wirth et al.
patent: 5175003 (1992-12-01), Goldman
patent: 5217720 (1993-06-01), Sekigawa et al.
patent: 5232706 (1993-08-01), Palomo Coll
patent: 5238686 (1993-08-01), Eichel et al.
patent: 5262172 (1993-11-01), Sipos
patent: 5273760 (1993-12-01), Oshlack et al.
patent: 5275824 (1994-01-01), Carli et al.
patent: 5294448 (1994-03-01), Ring et al.
patent: 5296233 (1994-03-01), Batista et al.
patent: 5302400 (1994-04-01), Sipos
patent: 5316772 (1994-05-01), Jurgens, Jr. et al.
patent: 5378474 (1995-01-01), Morella et al.
patent: 5396626 (1995-03-01), Kotwal et al.
patent: 5445829 (1995-08-01), Paradissis et al.
patent: 5464633 (1995-11-01), Conte et al.
patent: 5482718 (1996-01-01), Shah et al.
patent: 5536507 (1996-07-01), Abramowitz et al.
patent: 5614220 (1997-03-01), Hirakawa et al.
K. Nishimura et al.; Dosage Form Design for Improvement of Bioavailability of Levodopa VI: Formulation of Effervescent Enteric-Coated Tablets, J. Pharm. Sci. 73(7):942-946 (1984).
A. Gazzaniga et al.; time-dependent oral delivery systems for colon targeting, S.T.P. Pharma Sciences, 5(1):83-88 (1995).

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