Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-12-04
2007-12-04
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S284100, C514S337000
Reexamination Certificate
active
10412982
ABSTRACT:
Heterocyclic-substituted tricyclics of the formulaor a pharmaceutically acceptable salt thereof, wherein:the dotted line represents an optional single bond;represents an optional double bond;n is 0–2;Q is cycloalkyl, optionally substituted by R13and R14;R13and R14are independently selected from (C1–C6)alkyl, (C3–C8)cycloalkyl, —OH, (C1–C6)alkoxy, R27-aryl(C1–C6)alkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, halogen and haloalkyl; orR13and R14together form a spirocyclic or a heterospirocyclic ring of 3–6 atoms;Het is a mono- or bi-cyclic optionally substituted heteroaryl group; andB is a bond, alkylene, or optionally substituted alkenylene or alkynylene, wherein the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
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Chackalamannil Samuel
Greenlee William J.
Veltri Enrico P.
Wang Yuguang
Wu Wenxue
Coppins Janet L.
McKane Joseph K.
Reinhardt Gerald E.
Schering Corporation
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