Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-12
1997-09-30
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 18, 530331, 424 9464, 562445, 548535, A61K 3805
Patent
active
056725825
ABSTRACT:
4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailability. They have the formula ##STR1## for example ##STR2##
Brady Stephen F.
Feng Dong-Mei
Lewis S. Dale
Nutt Ruth F.
Shafer Jules A.
Lukton David
Merck & Co. , Inc.
Parr Richard S.
Schain Howard E.
Winokur Melvin
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