Three-dimensional structure of prostaglandin D synthase and...

Details Three-dimensional structure of prostaglandin D synthase and... Three-dimensional structure of prostaglandin D synthase and...

2002-09-27

2009-06-16

Noakes, Suzanne M. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S189000

Reexamination Certificate

active

07547532

ABSTRACT:
A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.

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