Three-dimensional stromal cell and tissue culture system

Details Three-dimensional stromal cell and tissue culture system Three-dimensional stromal cell and tissue culture system

1992-10-23

1995-12-26

Knode, Marian C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 435240241, 435240243, 623 15, C12N 500, A61F 210

Patent

active

054787394

ABSTRACT:
The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three-dimensional matrix while cycling the cultures between metabolically favorable and metabolically unfavorable (but noncytotoxic) conditions. The invention is based, at least in part, on the discovery that cycling the cultures in this manner optimizes the formation of extracellular matrix and produces an overall structure that more closely resembles naturally occurring tissue.

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Slivka et al, J. Cell Biol., 115 (3 Part 2), 1991, 236A.

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