Transgenic virus

Details Transgenic virus Transgenic virus

1997-01-22

1999-04-06

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4352351, 4353201, 47 581, A01N 6300, C12N 701, C12N 1586

Patent

active

058914315

ABSTRACT:
The present invention describes a new kind of transgenic virus which comprise insect transcription factors. Specifically, the transgenic insect virus comprises insect transcription factors that are involved in molting and metamorphosis. Such transgenic insect viruses are useful as biopesticides.

REFERENCES:
Winter, J. et al. Virology 211: 462-473, 1995.
Insecticidal Effects of an Insect-Specific Neurotoxin Expressed by a Recombinant Baculovirus, Maeda et al, Department of Entomology, University of California, Apr. 26, 1991, pp. 777-780.
Insecticidal Activity of a Bacterial Crystal Protein Expressed by a Recombinant Baculovirus in Insect Cells; Martens et al, Department of Virology, Agricultural University Wageningen, Apr. 26, 1990, pp. 2764-2770.
Expression and Effects of the juvenile hormone esterase in a baculoviruc vector; Hammock et al, NERC Institute of Virology, Nature vol. 344, Mar. 29, 1990, pp. 458-461.
Increased Insectional Effect by a Recombinant Baculovirus Carrying a Synthetic Diuretic Hormone Gene, Susumu Maeda, Zoecon Research Institute, Biochemical and Biophysical Research Communications, vol. 165, No. 3, Dec. 29, 1989, pp. 1177-1183.
Cummingham and House, 1984, Choristoneura fumiferana (clemens), Spruce budworm (Lepidoptera: Torticidae); B. Viruses: Application and Assessment. In Biological Control Programmes against Insect and Weeds in Canada 1969-1980, Kelleher, J.S. and Hulme, M.A., eds., Commonwealth Agricultural Bureau, Slough, England).
Bonning et al, Annu. Rev. Entomol. 85:437-446.
Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis, Lam et al., Development, 1997, 124: 1757-1769.
Genetic modification of an entomopoxvirus: deletion of the spheroidin gene does not affect virus replication in vitro, Palmer et al., J. Gen. Virol., 1995, 76:15-23.
Insecticidal activity of a recombinant baculovirus containing an antisensee c-myc fragment, Lee et al., J. Gen. Virol., 1997, 78:273-281.
Transient, nonlethal expression of genes in vertebrate cells by recombinant entomopoxviruses, Li et al., J. Virol, 1997, 71:9557-9562.

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