Thioformamide derivatives

Details Thioformamide derivatives Thioformamide derivatives

1995-01-30

1996-03-12

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544149, 546207, 549404, 549424, A61K 3135, C07D30908

Patent

active

054986346

ABSTRACT:
The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: ##STR1## wherein Y represents ##STR2## or the like [wherein R.sup.7 represents benzyloxy or the like; R.sup.11 and R.sup.12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, ##STR3## (wherein R.sup.14 and R.sup.15 each represent hydrogen, benzyl or the like) or the like];
Z represents --CH.sub.2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl or the like; and R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like.

REFERENCES:
patent: 4959385 (1990-09-01), Cook et al.
patent: 5064843 (1991-11-01), Hart et al.
patent: 5104883 (1992-04-01), Palfreyman et al.
J. of Medicinal Chemistry, vol. 35, 1992, pp. 3613-3624 Brown et al "Syntheses and biological activity of trans(.+-.)-N-Methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide etc." p. 3613 and Table I.

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