Thiazolidinedione derivatives as antidiabetic agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S263230, C514S266200, C514S256000, C514S269000, C514S274000, C514S275000, C544S277000, C544S293000, C544S311000, C544S312000, C544S317000, C544S319000, C544S321000, C544S323000, C544S006000

Reexamination Certificate

active

07001910

ABSTRACT:
The present invention refers to compounds of the general formula (I), to their possible pharmaceutically acceptable salts and tautomeric forms. The present invention also refers to a process for their production and to their use as antidiabetic and *hypoglycemic agents, alone or in combination with other antidiabetic agents, such as sulfonilureas or biguanides, as well as for the treatment of complications associated to the resistance to the insulin, such as hypertension, hyperuricemia or other cardiovascular, metabolic, endocrine conditions, or other conditions related with diabetes.

REFERENCES:
patent: 5002953 (1991-03-01), Hindley
patent: 0193256 (1986-09-01), None
patent: 9207838 (1992-05-01), None
Cantello, B.C.C., et al. “I[omega-(Heterocyclylamino)alkoxy]-2,4-thiazolidines as Potent Antihyperglycemic Agents” J. Med Chem, 1994, 37, 3977-3985 XP002901546.
Hulin, B, et al., “The Glitazone Family of Antidiabetic Agents”, Current Pharmaceutical Design, 1996, 2, 85-102 XP002901547.

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