Thermotolerant ribonuclease H

Details Thermotolerant ribonuclease H Thermotolerant ribonuclease H

2008-09-09

2008-09-09

Hutson, Richard G (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S195000, C536S023100, C536S023200

Reexamination Certificate

active

10380430

ABSTRACT:
Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.

REFERENCES:
patent: 5610066 (1997-03-01), Fuller et al.
patent: 2533671 (1996-06-01), None
patent: 11-32772 (1999-02-01), None
Itaya et al Molecular cloning of a ribonuclease H (RNase HI) gene from an extreme thermophile Thermus thermophilus HB8: a thermostable RNase H can functionally replace theEscherichia colienzyme in vivo. Nucleic Acids Res. Aug. 25, 1991;19(16):4443-9.
Ngo et al., Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox, in The Protein Folding Problem and Tertiary Structure Prediction, 1994, Merz et al. (ed.), Birkhauser, Boston, MA, pp. 433 and 492-495.
Klenk et al., SwissProt, Accession O29634, Gene AF0621.
Klenk et al., Genbank, Accession AE 001062.
Kawarabayasi et al., “Complete Sequence and Gene Organization of the Genome of a Hyper-Thermophilic Archaebacterium,Pyrococcus horikoshiiOT3”,DNA Research, vol. 5, pp. 55-76 (1998).
Kawarabayasi et al., SwissProt, Accession 059351, Gene PH1650.
Kawarabayasi et al., EMBL, Accession AP000006.
Nelson et al., “Evidence for Lateral Gene Transfer Between Archaea and Bacteria from Genome Sequence ofThermotoga maritima”, Nature, vol. 399, No. 6734, pp. 323-329 (May 27, 1999).
Nelson et al., SwissProt, Accession Q9X017, Gene TM0915.
Nelson et al., Genbank, Accession AE001755.
Haruki et al., “Gene Cloning and Characterization of Recombinant RNase HII from a Hyperthermophilic Archaeon”,Journal of Bacteriology, vol. 180, No. 23, pp. 6207-6214 (Dec. 1998).
Klenk et al., “The Complete Genome Sequence of the Hyperthermophilic, Sulphate-Reducing ArchaeonArchaeoglobus fulgidus”, Nature, vol. 390, No. 6665, pp. 364-370 (Nov. 27, 1997).
Kanaya et al., “Overproduction and Preliminary Crystallographic Study of Ribonuclease H fromEscherichia coli”, The Journal of Biological Chemistry, vol. 264, No. 20, pp. 11546-11549 (Jul. 15, 1989).
Wang et al., “Site-Specific Mutagenesis of the Human Interleukin-2 Gene: Structure-Function Analysis of the Cysteine Residues”,Science, vol. 224, pp. 1431-1433 (Jun. 29, 1984).
Brown et al., “Cultivation Techniques for Hyperthermophilic Archaebacteria: Continuous Culture ofPyrococcus furiosusat Temperatures Near 100° C.”,Applied and Environmental Microbiology, vol. 55, No. 8, pp. 2086-2088 (Aug. 1989).
Ohtani et al., “Identification of the Genes Encoding Mn2+-Dependent RNase HII and Mg2+-Dependent RNase HIII fromBacillus subtilis: Classification of RNases H into Three Families”,Biochemistry, vol. 38, pp. 605-618 (1999).
Pearson et al., “Improved Tools for Biological Sequence Comparison”,Proc. Natl. Acad. Sci., vol. 85, pp. 2444-2448 (Apr. 1988).
Database UniProt accession No. 029634.
Database UniProt accession No. 074035.
Database UniProt accession No. AAW97111.
Database EMBL accession No. AAX15332.
Database EMBL accession No. AB012613.
Database UniProt accession No. E71146.
Database UniProt accession No. E71145.
NCBI GenBank sequence database Accession No. AAB90620.
NCBI GenBank sequence database Accession No. AAD35996.

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