Thermostable Omega-Transaminases

Details Thermostable Omega-Transaminases Thermostable Omega-Transaminases

2008-01-15

2008-01-15

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

C435S069100, C435S191000, C435S193000, C435S280000, C536S023200

Reexamination Certificate

active

11627999

ABSTRACT:
Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound to a non-terminal, chirally substituted, carbon atom.

REFERENCES:
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patent: 6413752 (2002-07-01), Takashima
patent: 6727083 (2004-04-01), Takashima
patent: 2005/0009015 (2005-01-01), Chase
Shin et al., “Asymmetric synthesis of chiral amines with omega-transaminase,”Biotechnol. Bioengin.65, 206-11, 1999.
Shin & Kim, “Comparison of the ω-Transaminases from Different Microorganisms and Application to Production of Chiral Amines,”Biosci. Biotechnol. Biochem.65, 1782-88, 2001.

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