Therapeutic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S214030, C514S219000, C514S233200, C514S250000, C514S338000, C514S406000, C514S410000, C540S457000

Reexamination Certificate

active

07989438

ABSTRACT:
A class of macrocyclic compounds of formula (I), wherein R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

REFERENCES:
patent: 3480613 (1969-11-01), Walton
patent: 4182623 (1980-01-01), Kloek
patent: 5206382 (1993-04-01), Costa et al.
patent: 6323180 (2001-11-01), Llinas-Brunet et al.
patent: 6608027 (2003-08-01), Tsantrizos et al.
patent: 6777395 (2004-08-01), Bhat et al.
patent: 6955184 (2005-10-01), Friedrichs et al.
patent: 7153848 (2006-12-01), Hudyma et al.
patent: 7348425 (2008-03-01), Hudyma et al.
patent: 7470664 (2008-12-01), Holloway et al.
patent: 7662809 (2010-02-01), Ercolani et al.
patent: 7767660 (2010-08-01), Stansfield et al.
patent: 7781422 (2010-08-01), Stansfield et al.
patent: 2002/0019363 (2002-02-01), Ismaili et al.
patent: 2002/0107138 (2002-08-01), Hoveyda et al.
patent: 2003/0236216 (2003-12-01), Devos et al.
patent: 2004/0006007 (2004-01-01), Gosselin et al.
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0067901 (2004-04-01), Bhat et al.
patent: 2004/0229776 (2004-11-01), Chen et al.
patent: 2004/0229818 (2004-11-01), Llinas-Brunet
patent: 2004/0254159 (2004-12-01), Hasvold et al.
patent: 2004/0266668 (2004-12-01), Nakajima et al.
patent: 2005/0020503 (2005-01-01), Llinas-Brunet et al.
patent: 2005/0038240 (2005-02-01), Connolly et al.
patent: 2005/0119318 (2005-06-01), Hudyma et al.
patent: 2005/0239767 (2005-10-01), Chan et al.
patent: 2006/0100262 (2006-05-01), Conte et al.
patent: 2006/0257980 (2006-11-01), Li
patent: 2007/0027071 (2007-02-01), Holloway et al.
patent: 2007/0049593 (2007-03-01), Oka et al.
patent: 2007/0060565 (2007-03-01), Meanwell et al.
patent: 1719773 (2006-11-01), None
patent: 2337262 (1999-11-01), None
patent: 2430621 (2007-04-01), None
patent: WO9300334 (1993-01-01), None
patent: WO9637619 (1996-11-01), None
patent: 97/41211 (1997-11-01), None
patent: 98/22496 (1998-05-01), None
patent: 98/46630 (1998-10-01), None
patent: 99/07733 (1999-02-01), None
patent: 99/07734 (1999-02-01), None
patent: 99/38888 (1999-08-01), None
patent: 99/43691 (1999-09-01), None
patent: 99/50230 (1999-10-01), None
patent: 99/64442 (1999-12-01), None
patent: 00/09543 (2000-02-01), None
patent: 00/09546 (2000-02-01), None
patent: 00/25780 (2000-05-01), None
patent: 00/59929 (2000-10-01), None
patent: WO0068216 (2000-11-01), None
patent: 01/00622 (2001-01-01), None
patent: 01/47883 (2001-07-01), None
patent: 01/60379 (2001-08-01), None
patent: 01/68663 (2001-09-01), None
patent: 01/77091 (2001-10-01), None
patent: 01/77113 (2001-10-01), None
patent: 01/79246 (2001-10-01), None
patent: 01/90121 (2001-11-01), None
patent: 01/92282 (2001-12-01), None
patent: 02/04425 (2002-01-01), None
patent: 02/06246 (2002-01-01), None
patent: 02/18404 (2002-03-01), None
patent: 02/20497 (2002-03-01), None
patent: 02/32920 (2002-04-01), None
patent: 02/48116 (2002-06-01), None
patent: 02/48165 (2002-06-01), None
patent: 02/48172 (2002-06-01), None
patent: 02/051425 (2002-07-01), None
patent: 02/057287 (2002-07-01), None
patent: 02/057425 (2002-07-01), None
patent: WO0259321 (2002-08-01), None
patent: 02/100415 (2002-12-01), None
patent: 03/015755 (2003-02-01), None
patent: 03/026589 (2003-04-01), None
patent: 03/026675 (2003-04-01), None
patent: 03/062192 (2003-07-01), None
patent: 03/062211 (2003-07-01), None
patent: 03/064455 (2003-08-01), None
patent: 03/068244 (2003-08-01), None
patent: 03/093290 (2003-11-01), None
patent: 03/099274 (2003-12-01), None
patent: 2004/000858 (2003-12-01), None
patent: WO03099824 (2003-12-01), None
patent: 2004/002422 (2004-01-01), None
patent: 2004/002999 (2004-01-01), None
patent: 2004/003000 (2004-01-01), None
patent: 2004/003138 (2004-01-01), None
patent: 2004/007512 (2004-01-01), None
patent: 2004/011478 (2004-02-01), None
patent: 2004/013300 (2004-02-01), None
patent: 2004/028481 (2004-04-01), None
patent: 2004/041201 (2004-05-01), None
patent: WO2004065367 (2004-08-01), None
patent: WO2004087714 (2004-10-01), None
patent: 2004/093915 (2004-11-01), None
patent: 2004/103996 (2004-12-01), None
patent: 2004/110442 (2004-12-01), None
patent: 2005/003147 (2005-01-01), None
patent: 2005/016927 (2005-02-01), None
patent: 2005/023819 (2005-03-01), None
patent: 2005/034941 (2005-04-01), None
patent: 2005/046712 (2005-05-01), None
patent: 2005/070955 (2005-08-01), None
patent: WO2005/080388 (2005-09-01), None
patent: WO2005080399 (2005-09-01), None
patent: 2006/008556 (2006-01-01), None
patent: WO2006007693 (2006-01-01), None
patent: WO2006020082 (2006-02-01), None
patent: 2006/021341 (2006-03-01), None
patent: 2006/027628 (2006-03-01), None
patent: WO2006029912 (2006-03-01), None
patent: WO2006046030 (2006-05-01), None
patent: WO2006046039 (2006-05-01), None
patent: WO2006052013 (2006-05-01), None
patent: 2006/119061 (2006-11-01), None
patent: 2006/119975 (2006-11-01), None
patent: 2007/015787 (2007-02-01), None
patent: 2007/015855 (2007-02-01), None
patent: 2007/016441 (2007-02-01), None
patent: 2007/028789 (2007-03-01), None
patent: WO2007029029 (2007-03-01), None
patent: WO2007033032 (2007-03-01), None
patent: WO2007033175 (2007-03-01), None
patent: WO2007054741 (2007-05-01), None
patent: 2007/131966 (2007-11-01), None
patent: WO2007129119 (2007-11-01), None
patent: WO2007131966 (2007-11-01), None
patent: 2007/145894 (2007-12-01), None
patent: 2007/148135 (2007-12-01), None
patent: 2008/051475 (2008-05-01), None
patent: 2008/051477 (2008-05-01), None
patent: 2008/051514 (2008-05-01), None
patent: 2008/057028 (2008-05-01), None
patent: 2008/057208 (2008-05-01), None
patent: 2008/057209 (2008-05-01), None
patent: 2008/075103 (2008-06-01), None
patent: WO2008101665 (2008-08-01), None
patent: 2008/112108 (2008-09-01), None
patent: 2009/005687 (2009-01-01), None
patent: 2009/010804 (2009-01-01), None
patent: 2009/064955 (2009-05-01), None
patent: 2009/064975 (2009-05-01), None
V. Lohmann et al., “Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line,” 285 Science 110-13 (1999).
Volker Lohmann et al., “Selective stimulation of Hepatitis C Virus and Pestivirus NS5B RNA Polymerase Activity by GTP,” 274(16) The Journal of Biological Chemistry 10807-15 (1999).
W. Clark Still et al., “Rapid Chromatographic Technique for Preparative Separations with Moderate Resolution,” 43(14) Journal of Organic Chemistry 2923-25 (1978).
J.M. Travins & F.A. Etzkorn, “Facile synthesis of D-amino acids from an L-serine-derived axiridine,” 39 Tetrahedron Letters 9389-92 (1998).
Tim Mosmann, “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays,” 65 Journal of Immunological Methods 55-63 (1983).
Paul Blaney et al., “Fused and bridged bi- and tri-cyclic lactams via sequential metallo-azomethine ylide cycloaddition-lactamisation,” 58(9) Tetrahedron 1719(37) (2002).
Jean-Yves Winum et al., “N-(tert-Butoxycarbony1)-N-[4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl] azanide: A New Sulfamoylating Agent. Structure and Reactivity toward Amines,” 3(14) Organic Letters 2241-2243 (2001).
Eric P. Gillis & Martin D. Burke, “A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki-Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks,” 129(21) Journal of the American Chemical Society 6716-17 (2007).
Ana Martinez et al., “Benzothiadiazine Dioxides (BTD) Derivatives as Non-nucleoside Human Cytomegalovirus (HCMV) Inhibitors. Study of Structural Requirements for Biological Activity,” 11(11) Bioorganic & Medicinal Chemistry 2395-402 (2003).
A. Srikrishna et al., “Enantiospecific construciton of the BC-ring system of taxanes,” 45(14) Tetrahedron Letters 2939-42 (2004).
Nathalie Goudreau & Montse Llinas-Brunet, “The therapeutic pote

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