Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-01-26
1991-12-03
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544389, A01N 4360, A61K 31495, C07D24104
Patent
active
050700898
ABSTRACT:
A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is disclosed.
REFERENCES:
patent: 4112091 (1978-09-01), Nesvadba
Florvall, Dopamine .beta.-hydroxylase Inhibitors, Acta Pharm, Sucecia 1970, 7(1)7-22.
Takemoto, N-Carbodithio, Derivatives of Piperazine, CA 55:27336, Yakugaku Kankyu 33 1-6 (1961).
Masaki Mitsuo
Matsukura Hitoshi
Satoh Masaru
Takeda Hiromitsu
Yamakawa Tomio
Nippon Chemiphar Co., Ltd.
Tsung Fred
Wax Robert A.
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